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Research Associate, Celgene

Position
(Contract) Research Associate

Supervisor
Pui (Bill) Wong

Department
Translational Developement

Prerequisites
The candidate must have a Bachelors degree in the Life Sciences with 5 or more years industry experience or Masters degree, with a minimum of 2 years of additional experience in a research environment.

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Translational Development at Celgene is charged with understanding which patients will respond to particular drugs and drug combinations, and which will not. The group provides a crucial bridge between discovery and early clinical development. It also works to better understand and deploy drugs ranging from novel discovery-stage agents to Celgene’s approved, marketed therapeutics. Most typically, translational scientists engage with discovery project teams to select targets and define disease area strategies, and then integrate into Early Development Teams to provide scientific leadership for early clinical programs from candidate nomination to proof of principle (i.e., Phase 2A) studies. These latter teams are responsible for rapidly and cost-effectively moving projects through early safety, efficacy and signal searching studies, and for ultimately providing a robust roadmap for registration studies to late development. Scientific questions and issues including target validation approaches, disease model selection, biomarker selection and biomarker assay development, pharmacokinetic and pharmacodynamic assessment of compounds, combination strategies, and trial design are central to the group’s work and lead to extensive interactions with Discovery, Early Clinical Development, Clinical Pharmacology, and disease area teams within Celgene.

The candidate will work with our translational development teams by contributing to the development and execution of laboratory experiments to understand the activity and mechanism of cancer drugs and identifying markers of response or resistance. The successful candidate will have solid technical experience, enthusiasm for working with cross-functional teams and project teams to support preclinical and clinical programs, and a strong desire to contribute to the efficient development and optimal clinical application of new anticancer drugs.

Technical Skills:

· Expertise in cell culture of mammalian cell lines and primary cells

· Cell-based assays for growth/viability and signal transduction

· Measurement and manipulation of gene expression (RT-PCR, si/shRNA)

· Analysis of cell surface marker and intracellular protein by flow cytometry

· Experience with in vivo studies in mice including xenograft, imaging etc.

· Immunohistochemistry and immunofluorescence technique

· Core cell biology skills including microscopy, Westerns, immunoprecipitation, ELISA etc

· Knowledge of oncology and tumor immunology is a plus

Scientific Capabilities:

· Able to independently design experiments to address a scientific question; analyze and present data

· Self-directed use of literature to inform project strategies and select experimental methods

· Able to critically analyze and interpret data

· First-rate skills in spotting artifacts and troubleshooting assays

· Able to select, test and validate protocols and methods

· Critically assess project(s) and formulate ideas

· Solid understanding of scientific mechanisms and experimental techniques, with knowledge of cancer cell biology preferable

Other Attributes:

· Maintain positive and productive working relationships with colleagues

· Improve efficiency and productivity within group or project

· Understands and aligns with departmental goals and prioritization

· Viewed as an experienced resource within the department

· Ability to prioritize and manage time efficiently

· Excellent oral and written communication skills

· Detail-oriented with the ability to identify and implement creative solutions

· Strong motivation to carry out rigorous, well-controlled experiments

· Strong motivation to improve cancer treatment

Responsibilities:

· Execute experiments independently

· Interpret and discuss data

· Troubleshoot

· Train other research associates and scientists in lab assays of expertise

· Understand the context, impact and timely communication of data.

· Search literature for targeted information.

· Work with human blood and tissue samples

· Understand and execute on role tasks

· Actively participate in the development of cell-based assays for mechanistic studies, including biomarker work

· Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail

· Meticulous record keeping

· Willingly share information and resources

· Interact with manager and project team to review data and plan next steps

· Prepare and present work at group meetings

· Flexible to changing priorities

· Respectful of laboratory safety policies and practices

Experience:

· The candidate must have a Bachelors degree in the Life Sciences with 5 or more years industry experience or Masters degree, with a minimum of 2 years of additional experience in a research environment.

· Must be willing to work with a highly motivated team, pursuing goals aggressively.

· The candidate will be technically superb, independent, detail oriented, well organized, and enjoy working in a fast paced environment.
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